2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W015815
    6-Methylnicotinamide 6960-22-1
    6-Methylnicotinamide, a derivate of nicotinamide, is an endogenous metabolite. A sudden increase of 6-methylnicotinamide in the acute stages of intracerebral hemorrhage (ICH) exacerbates neurological damages.
    6-Methylnicotinamide
  • HY-W060470
    1-Methyl-4-imidazoleacetic acid hydrochloride 35454-39-8 ≥98.0%
    1-Methyl-4-imidazoleacetic acid hydrochloride is a stable metabolite of Histamine (HY-B1204) that is produced by the oxidation of the primary metabolite, N-methylhistamine.
    1-Methyl-4-imidazoleacetic acid hydrochloride
  • HY-W068771
    (E)-3-(4-Methoxyphenyl)acrylic acid 943-89-5 ≥98.0%
    (E)-3-(4-Methoxyphenyl)acrylic acid (compound 3) is isolated from Arachis hypogaea, Scrophularia buergeriana Miquel, Aquilegia vulgaris, Anigozanthos preissii and so on. (E)-3-(4-Methoxyphenyl)acrylic acid shows significant hepatoprotective activity, anti-amnesic, cognition-enhancing activity, antihyperglycemic, and neuroprotective activities.
    (E)-3-(4-Methoxyphenyl)acrylic acid
  • HY-W072385
    1,2-Dibromo-4,5-methylenedioxybenzene 5279-32-3 ≥98.0%
    1,2-Dibromo-4,5-methylenedioxybenzene is an impurity in the synthesis of amphetamines.
    1,2-Dibromo-4,5-methylenedioxybenzene
  • HY-W089856
    Chlorobutanol hemihydrate 6001-64-5 ≥98.0%
    Chlorobutanol hemihydrate is an antimicrobial agent with oral activity, also possessing preservative effects. Chlorobutanol hemihydrate exhibits resistance to a variety of Gram-positive and Gram-negative bacteria, as well as several fungal spores and fungi, and is widely used in the food and cosmetics industries.
    Chlorobutanol hemihydrate
  • HY-W090309
    Monosodium 2-sulfoterephthalate 19089-60-2 98.99%
    Monosodium 2-sulfoterephthalate (8) is a glutamate carboxypeptidase II inhibitor.
    Monosodium 2-sulfoterephthalate
  • HY-W111999
    1-Benzyl-3-phenylthiourea 726-25-0 99.94%
    1-Benzyl-3-phenylthiourea is a sensor material for detecting nerve agents and related simulants, and has biosensor activity. 1-Benzyl-3-phenylthiourea can be used to increase the sensitivity of sensors to nerve agents and enhance detection capabilities. The reaction characteristics of 1-Benzyl-3-phenylthiourea are similar to those of nerve agents and their simulants, making it show good results in detection.
    1-Benzyl-3-phenylthiourea
  • HY-W685943
    Heptaminol 372-66-7 ≥98.0%
    Heptaminol is a fatty amine with pressor properties and a potential antihypotension agent. Heptaminol is also a competitive inhibitor of norepinephrine uptake and an inhibitor of nicotine-induced catecholamine release (IC50: 650 μM). Heptaminol does not inhibit norepinephrine release induced by 59 mM K+ but rather inhibits high-affinity Na+-dependent norepinephrine uptake.
    Heptaminol
  • HY-W747599
    Ganglioside GQ1b (bovine) sodium 68652-37-9 ≥98.0%
    Ganglioside GQ1b (bovine) sodium promotes neurite outgrowth during early neuronal differentiation. Ganglioside GQ1b (bovine) sodium controls the neuronal differentiation process in mESCs.
    Ganglioside GQ1b (bovine) sodium
  • HY-Y0258S1
    Benzocaine-(ethyl-d5) 1219803-76-5 99.0%
    Benzocaine-(ethyl-d5) is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.
    Benzocaine-(ethyl-d5)
  • HY-N0229S13
    L-Alanine-d7 74280-71-0 99.55%
    L-Alanine-d7 is the deuterium labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-d7
  • HY-W010388R
    Creatine (Standard) 57-00-1
    Creatine (Standard) is the analytical standard of Creatine. This product is intended for research and analytical applications. Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.
    Creatine (Standard)
  • HY-W012722R
    4-Methyl-2-oxopentanoic acid (Standard) 816-66-0
    4-Methyl-2-oxopentanoic acid (Standard) is the analytical standard of 4-Methyl-2-oxopentanoic acid. This product is intended for research and analytical applications. 4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid), an abnormal metabolite, is both a neurotoxin and a metabotoxin.
    4-Methyl-2-oxopentanoic acid (Standard)
  • HY-W014589R
    2,4-Di-tert-butylphenol (Standard) 96-76-4
    2,4-Di-tert-butylphenol (Standard) is the analytical standard of 2,4-Di-tert-butylphenol (HY-W014589). This product is intended for research and analytical applications. 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities, and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of pharmaceuticals and fragrances.
    2,4-Di-tert-butylphenol (Standard)
  • HY-W015169A
    5-Methoxytryptamine hydrochloride 66-83-1 ≥98.0%
    5-Methoxytryptamine hydrochloride, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine hydrochloride has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine hydrochloride is also a potent antioxidant and has radioprotective action.
    5-Methoxytryptamine hydrochloride
  • HY-W018061C
    (R,R)-Traxoprodil 134234-13-2 99.00%
    (R,R)-Traxoprodil is the the (R,R)-enantiomer of Traxoprodil (HY-W018061). Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.
    (R,R)-Traxoprodil
  • HY-W011873S2
    Palmitoleic acid-13C16 2483735-57-3 99.20%
    Palmitoleic acid-13C16 is the 13C labeled Palmitoleic acid. Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.
    Palmitoleic acid-13C16
  • HY-W015309S3
    Decanoic acid-d5 1219803-00-5 98.30%
    Decanoic acid-d5 is the deuterium labeled Decanoic acid. Decanoic acid, a component of medium chain triclycerides, is a brain-penetrant and non-competitive inhibitor of AMPA receptor. Decanoic acid has antiseizure effects.
    Decanoic acid-d5
  • HY-W016498S1
    Paraxanthine-13C4,15N3 1173018-79-5 ≥99.0%
    Paraxanthine-13C4,15N3 is the 13C-labeled and 15N-labeled Paraxanthine. Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
    Paraxanthine-13C4,15N3
  • HY-W017443S1
    L-Asparagine-amide-15N monohydrate 204451-47-8 99.80%
    L-Asparagine-amide-15N monohydrate is the 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine-amide-15N monohydrate
Cat. No. Product Name / Synonyms Application Reactivity